H-FTAA
H-FTAA is a luminescent conjugated oligothiophene (LCO) probe. h-FTAA can selectively bind to amyloid protein aggregates (such as Aβ plaques) and distinguish different conformations of the protein aggregates through changes in fluorescence signals. h-FTAA significantly reduces the neurotoxicity of Aβ1-42 and the Arctic mutant Aβ (AβArc), thereby protecting SH-SY5Y neuroblastoma cells. h-FTAA can be used to dynamically track the formation and maturation process of Aβ plaques[1][2].
Product Specifications
CAS Number
1352477-26-9
UNSPSC
12352100
Target
Amyloid-β; Fluorescent Dye
Related Pathways
Neuronal Signaling; Others
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C(C1=CC=C(C2=CC=C(C3=CC(CC(O)=O)=C(C4=CC=C(C5=C(CC(O)=O)C=C(C6=CC=C(C7=CC=C(C(O)=O)S7)S6)S5)S4)S3)S2)S1)O
Molecular Formula
C34H20O8S7
Molecular Weight
780.97
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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