Triptolide-6-succinate-β-D-glucose

Triptolide-6-succinate-β-D-glucose (Compound 2) is a glucose-conjugated derivative of Triptolide (HY-32735) . Triptolide-6-succinate-β-D-glucose is a tumor-selective prodrug targeting glucose transporters (GLUT) . Triptolide-6-succinate-β-D-glucose can induce the degradation of the RPB subunit of RNA polymerase II. Triptolide-6-succinate-β-D-glucose inhibits the proliferation of HEK293T cells with an IC50 value of 268 nM. Triptolide-6-succinate-β-D-glucose can be used for the research of cancer, such as prostatic cancer[1].

Product Specifications

CAS Number

[2003231-25-0]

UNSPSC

12352005

Target

DNA/RNA Synthesis; Drug Derivative; GLUT

Related Pathways

Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

[H][C@]1(O[C@@]12[C@H](OC(CCC(O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)=O)=O)[C@@]4(C(C)C)O[C@@]54[H])C[C@]6(C(CO7)=C(CC[C@]6(C)[C@]82O[C@]85[H])C7=O)[H]

Molecular Formula

C30H38O14

Molecular Weight

622.61

References & Citations

[1]He QL, et al. Targeted Delivery and Sustained Antitumor Activity of Triptolide through Glucose Conjugation. Angew Chem Int Ed Engl. 2016 Sep 19;55 (39) :12035-9. doi: 10.1002/anie.201606121