OZD-MET 01
OZD-MET 01 is a chaperone-med iatedprotein PROTAC-type MET degrader. OZD-MET 01 can inhibit proliferation of H596 and H1437 cells with IC50 values of 3.07 and 3.5 μM. OZD-MET 01 can be used for the research of cancer, such as non-small cell lung cancer[1]. (Structure Note: Pink: MET ligand (HY-50878) ; Blue: chaperone ligand (HY-112078) ; MET ligand-Linker: (HY-176950) )
Product Specifications
CAS Number
[3048497-38-4]
UNSPSC
12352005
Target
C-Met/HGFR; PROTACs
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
C[C@@H](OC1=CC(C2=CN(N=C2)C3CCN(C(OCCOCCNC(C4=CC(CN(C(C5=CC(C(C)C)=C(O)C=C5O)=O)C)=CC=C4)=O)=O)CC3)=CN=C1N)C6=C(Cl)C(F)=CC=C6Cl
Molecular Formula
C45H50Cl2FN7O8
Molecular Weight
906.83
References & Citations
[1]Joo-hoon AHN, et al. Met protein degradation inducing compound. WO2024144088A1. 2025-06-27|[2]Joo-hoon AHN, et al. Met protein degradation inducing compound. WO2024144088A1. 2025-06-27
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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