UAB116

UAB116 is a Liver X Receptor (LXR) /Retinoid X Receptor (RXR) agonist. UAB116 can decreases metastatic phenotype in hepatoblastoma by inhibiting the Wnt/β-Catenin pathway via upregulation of TRIM29. UAB116 can reduce proliferation, stemness and invasiveness of metastatic hepatoblastoma cells[1].

Product Specifications

CAS Number

[3031463-59-6]

UNSPSC

12352211

Target

LXR; RAR/RXR; Wnt; β-catenin

Related Pathways

Metabolic Enzyme/Protease; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CCC(C)C(CCC/C1=C\C(C)=C/C=C/C(C)=C/C(O)=O)=C1CCC(C)C

Molecular Formula

C25H38O2

Molecular Weight

370.57

References & Citations

[1]Butey S, et al. A Novel Rexinoid Agonist, UAB116, Decreases Metastatic Phenotype in Hepatoblastoma by Inhibiting the Wnt/β-Catenin Pathway via Upregulation of TRIM29. Int J Mol Sci. 2025 Apr 22;26 (9) :3933.