UAB116
UAB116 is a Liver X Receptor (LXR) /Retinoid X Receptor (RXR) agonist. UAB116 can decreases metastatic phenotype in hepatoblastoma by inhibiting the Wnt/β-Catenin pathway via upregulation of TRIM29. UAB116 can reduce proliferation, stemness and invasiveness of metastatic hepatoblastoma cells[1].
Product Specifications
CAS Number
[3031463-59-6]
UNSPSC
12352211
Target
LXR; RAR/RXR; Wnt; β-catenin
Related Pathways
Metabolic Enzyme/Protease; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CCC(C)C(CCC/C1=C\C(C)=C/C=C/C(C)=C/C(O)=O)=C1CCC(C)C
Molecular Formula
C25H38O2
Molecular Weight
370.57
References & Citations
[1]Butey S, et al. A Novel Rexinoid Agonist, UAB116, Decreases Metastatic Phenotype in Hepatoblastoma by Inhibiting the Wnt/β-Catenin Pathway via Upregulation of TRIM29. Int J Mol Sci. 2025 Apr 22;26 (9) :3933.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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