IMU-856
IMU-856 is an orally active and systemic action SIRT6 small molecule regulator. IMU-856 effectively and selectively inhibits the deacetylase activity of SIRT6, while increasing the protein level of SIRT6. IMU-856 can restore intestinal barrier function and can be used for research on celiac disease[1].
Product Specifications
CAS Number
[2303528-97-2]
UNSPSC
12352005
Target
Sirtuin
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Inflammation/Immunology
Smiles
CN1C([C@@H]2CC[C@H](CC2)C3=CN(N=C3)[C@@H]4CC[C@H](CC4)N5CC6(CCO6)C5)=NN=C1COC7=CC(C(F)(F)F)=CC=N7
Molecular Formula
C30H38F3N7O2
Molecular Weight
585.66
References & Citations
[1]Daveson AJM, et al. Safety, clinical activity, pharmacodynamics, and pharmacokinetics of IMU-856, a SIRT6 modulator, in coeliac disease: a first-in-human, randomised, double-blind, placebo-controlled, phase 1 trial. Lancet Gastroenterol Hepatol. 2025 Jan;10 (1) :44-54.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT6
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