AMPA receptor modulator-10

AMPA receptor modulator-10 (Compound 9a) is an orally active AMPA receptor (AMPAR) positive allosteric modulator. AMPA receptor modulator-10 exhibits potent activity (pEC50 = 5.0) on the GluA2 subtype of AMPAR, significantly enhancing glutamate-induced calcium influx and current responses. AMPA receptor modulator-10 can reverse the memory impairment induced by Scopolamine (HY-N0296) and enhance cognitive function. AMPA receptor modulator-10 can be used for the research of neurological disease, such as schizophrenia[1].

Product Specifications

CAS Number

[620940-01-4]

UNSPSC

12352005

Target

IGluR

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

98.78

Smiles

O=C(N1CCCC1)C2=CC=C(N3N=C(C(F)(F)F)C4=C3CCCC4)C=C2

Molecular Formula

C19H20F3N3O

Molecular Weight

363.38

References & Citations

[1]Ward SE, et al. Integration of lead optimization with crystallography for a membrane-bound ion channel target: discovery of a new class of AMPA receptor positive allosteric modulators. J Med Chem. 2011 Jan 13;54 (1) :78-94.