GQC-05
GQC-05 (NSC338258), Ellipticine (HY-15753) derivative, is potent and selective c-Myc G-quadruplex (c-Myc G4) stabilizer with KD values of 0.1-1.43 μM. GQC-05 can reduce Myc expression and induce cancer cells apoptosis. GQC-05 can be used for the research of cancer, such as Burkitt lymphoma[1].
Product Specifications
Product Name Alternative
NSC 338258
UNSPSC
12352005
Target
Apoptosis; c-Myc; Drug Derivative
Related Pathways
Apoptosis; Others
Field of Research
Cancer
Smiles
CN(C)CCOC1=CC=C2C(C(C(C)=C3C(C=CN=C3)=C4C)=C4N2)=C1
Molecular Formula
C21H23N3O
Molecular Weight
333.43
References & Citations
[1]Brown RV, et al. Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex. J Biol Chem. 2011 Nov 25;286 (47) :41018-27.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-177872/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
CAS Number
[501662-77-7]
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