GQC-05
GQC-05 (NSC338258), Ellipticine derivative, is potent and selective c-Myc G-quadruplex (c-Myc G4) stabilizer with KD values of 0.1-1.43 μM. GQC-05 can reduce Myc expression and induce cancer cells apoptosis. GQC-05 can be used for the research of cancer, such as Burkitt lymphoma[1].
Product Specifications
CAS Number
501662-77-7
Product Name Alternative
NSC 338258
UNSPSC
12352005
Target
Apoptosis; c-Myc; Drug Derivative
Related Pathways
Apoptosis; Others
Field of Research
Cancer
Smiles
CN(C)CCOC1=CC=C2C(C(C(C)=C3C(C=CN=C3)=C4C)=C4N2)=C1
Molecular Formula
C21H23N3O
Molecular Weight
333.43
References & Citations
[1]Brown RV, et al. Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex. J Biol Chem. 2011 Nov 25;286 (47) :41018-27.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
VAng-Cr4140-500gEcoli 500 µg (E. coli)
Recombinant CAdV-1 PX Protein (aa 22-39) (strain CLL)
Sign In for Pricing
View Details 
PKSH033944-01 10 µg
Recombinant Human IL-7 Receptor Subunit alpha/IL-7RA/CD127 (C-6His)
Sign In for Pricing
View Details PKSH033944-02 50 µg
Recombinant Human IL-7 Receptor Subunit alpha/IL-7RA/CD127 (C-6His)
Sign In for Pricing
View Details ![FHOD1 Mouse Antibody [Clone ID: M352]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
![Mouse Monoclonal CGRP Antibody (4) [DyLight 594]](https://cdn.genprice.uk/genprice/uk/genprice3.webp)
NBP3-00519DL594 0.1 mL
Mouse Monoclonal CGRP Antibody (4) [DyLight 594]
Sign In for Pricing
View Details