Aβ aggregation-IN-4

Aβ aggregation-IN-4 can alleviate the neurotoxicity of amyloid-β protein (Aβ) and significantly reduce the level of oligomeric complexes of Aβ (Aβ-OCs) . Aβ aggregation-IN-4 does not decrease the level of amyloid-β protein (Aβ) . Aβ aggregation-IN-4 attenuates Aβ oligomerization and prevents oligomer-induced death of primary cortical neurons. Aβ aggregation-IN-4 can be used for the study of Alzheimer’s disease (AD) [1].

Product Specifications

CAS Number

[603113-07-1]

UNSPSC

12352005

Target

Amyloid-β

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Smiles

[H][C@]12C[C@H](CCC1=CC3=C(O2)C=C(OC3=O)C)[C@@H](CN4C=NC(N)=C5C4=NC=N5)C

Molecular Formula

C21H23N5O3

Molecular Weight

393.44

References & Citations

[1]Maezawa I, et al. A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-beta oligomeric complexes. J Neurochem. 2006 Jul;98 (1) :57-67.