ARC5690 (sodium)
ARC5690 sodium is an anti-mouse P-selectin aptamer. ARC5690 bound to recombinant mouse P-selectin with a KD of approximately 15pM in vitro. ARC5690 showed a significant anti-inflammatory effect
Product Specifications
UNSPSC
12352208
Target
P-selectin
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
[ARC5690(sodium)]
References & Citations
[1]Gutsaeva DR, Parkerson JB, Yerigenahally SD, Kurz JC, Schaub RG, Ikuta T, Head CA. Inhibition of cell adhesion by anti-P-selectin aptamer: a new potential therapeutic agent for sickle cell disease. Blood. 2011 Jan 13;117 (2) :727-35.|[2]Diana Gutsaeva, James Parkerson, Robert G Schaub, Jeffrey Kurz, Alvin Head. Single-Stranded Oligonucleotide Binding to P-Selectin Inhibits Adhesion of Sickle Red Blood Cells and Leukocytes to Endothelial Cells in Sickle Cell Model Mice: Novel Therapeutics for Vaso-Occlusive Episodes. Blood, Volume 114, Issue 22,2009, Page 1545, ISSN 0006-4971.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Curated Selection
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