VRNPs degrader-1

VRNPs degrader-1 is a potent PROTAC viral ribonucleoproteins (vRNPs) degrader. vRNPs degrader-1 shows broad-spectrum anti-influenza A viruses (IAV) activity by targeting the conserved 5′ end of viral RNA, thereby inducing proteasomal degradation of viral proteins. vRNPs degrader-1 inhibits H1N1, H9N2, and H3N2 infection in mice. vRNPs degrader-1 can be used for influenza research[1].

Product Specifications

UNSPSC

12352005

Target

Influenza Virus; PROTACs

Related Pathways

Anti-infection; PROTAC

Field of Research

Infection

Smiles

CC(N=CS1)=C1C(C=C2)=CC=C2CNC([C@H]3N(C([C@@H](NC(COCCOCCOCCN(N=N4)C(C5=C(CN6C(C[3'-TCATCTTTGTTCC-5'])=O)C=CC=C5)=C4C7=C6C=CC=C7)=O)C(C)(C)C)=O)C[C@H](O)C3)=O

References & Citations

[1]Liu YY, et al. Harnessing Multiplexed Proteolysis-Targeting Chimera for Comprehensive Influenza A Virus Targeting. J Am Chem Soc. 2025 Nov 12;147 (45) :41331-41341.