VRNPs degrader-1
VRNPs degrader-1 is a potent PROTAC viral ribonucleoproteins (vRNPs) degrader. vRNPs degrader-1 shows broad-spectrum anti-influenza A viruses (IAV) activity by targeting the conserved 5′ end of viral RNA, thereby inducing proteasomal degradation of viral proteins. vRNPs degrader-1 inhibits H1N1, H9N2, and H3N2 infection in mice. vRNPs degrader-1 can be used for influenza research[1].
Product Specifications
UNSPSC
12352005
Target
Influenza Virus; PROTACs
Related Pathways
Anti-infection; PROTAC
Field of Research
Infection
Smiles
CC(N=CS1)=C1C(C=C2)=CC=C2CNC([C@H]3N(C([C@@H](NC(COCCOCCOCCN(N=N4)C(C5=C(CN6C(C[3'-TCATCTTTGTTCC-5'])=O)C=CC=C5)=C4C7=C6C=CC=C7)=O)C(C)(C)C)=O)C[C@H](O)C3)=O
References & Citations
[1]Liu YY, et al. Harnessing Multiplexed Proteolysis-Targeting Chimera for Comprehensive Influenza A Virus Targeting. J Am Chem Soc. 2025 Nov 12;147 (45) :41331-41341.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
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