Orexin receptor antagonist 7
Orexin receptor antagonist 7 (Compound 34) is an antagonist of the orexin receptor (OX1R), with a Ki value of 4.05 nM. Orexin receptor antagonist 7 shows no detectable activity towards OX2R and has very low affinities for the three opioid receptors (μ, δ, κ) (Ki > 1,000 nM) . Orexin receptor antagonist 7 can be used for research on opioid addiction[1].
Product Specifications
CAS Number
2096315-41-0
UNSPSC
12352005
Target
Orexin Receptor (OX Receptor)
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O[C@]12[C@@]34C5=C(C[C@@]2([H])N(CC4)S(=O)(C6=CC=CC=C6)=O)C=CC(OC)=C5O[C@@]3([H])[C@@H](CC1)N(C)C(/C=C/C7=COC=C7)=O
Molecular Formula
C31H32N2O7S
Molecular Weight
576.66
References & Citations
[1]Nagase H, et al. Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies. J Med Chem. 2017 Feb 9;60 (3) :1018-1040.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
OX1 Receptor
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