Orexin receptor antagonist 7

Orexin receptor antagonist 7 (Compound 34) is an antagonist of the orexin receptor (OX1R), with a Ki value of 4.05 nM. Orexin receptor antagonist 7 shows no detectable activity towards OX2R and has very low affinities for the three opioid receptors (μ, δ, κ) (Ki > 1,000 nM) . Orexin receptor antagonist 7 can be used for research on opioid addiction[1].

Product Specifications

CAS Number

[2096315-41-0]

UNSPSC

12352005

Target

Orexin Receptor (OX Receptor)

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O[C@]12[C@@]34C5=C(C[C@@]2([H])N(CC4)S(=O)(C6=CC=CC=C6)=O)C=CC(OC)=C5O[C@@]3([H])[C@@H](CC1)N(C)C(/C=C/C7=COC=C7)=O

Molecular Formula

C31H32N2O7S

Molecular Weight

576.66

References & Citations

[1]Nagase H, et al. Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies. J Med Chem. 2017 Feb 9;60 (3) :1018-1040.