IDeg-6

IDeg-6 is a selective molecular glue degrader that targets IDO1 with a DC50 of 6.5 nM. iDeg-6 can competitively bind to the heme binding site of apo-IDO1, preventing heme binding and inhibiting the enzymatic reaction that converts tryptophan into kynurenine by IDO1 (IC50 = 1.6 μM) . iDeg-6 can be used for the researches of cancer, infection and neurological disease, such as melanoma[1].

Product Specifications

UNSPSC

12352005

Target

Indoleamine 2,3-Dioxygenase (IDO) ; Molecular Glues

Related Pathways

Metabolic Enzyme/Protease; PROTAC

Field of Research

Cancer; Infection; Neurological Disease

Smiles

C#CC1=CC=C(C=C1)NC(OC[C@@]23[C@H](C[C@@H]4C[C@]2([H])CN(C3)S(C5=C(C)C=C(C(C)(C)C)C=C5)(=O)=O)C4(C)C)=O

Molecular Formula

C32H40N2O4S

Molecular Weight

548.74

References & Citations

[1]Hennes E, et al. Identification of a Monovalent Pseudo-Natural Product Degrader Class Supercharging Degradation of IDO1 by its native E3 KLHDC3. bioRxiv [Preprint]. 2025 Jan 17:2024.07.10.602857.