IDeg-3
IDeg-3 is a selective molecular glue degrader that targets IDO1. iDeg-3 can competitively bind to the heme binding site of apo-IDO1, preventing heme binding and inhibiting the enzymatic reaction that converts tryptophan into kynurenine by IDO1 (IC50 = 46 nM) . iDeg-3 can be used for the researches of cancer, infection and neurological disease, such as melanoma[1].
Product Specifications
UNSPSC
12352005
Target
Indoleamine 2,3-Dioxygenase (IDO) ; Molecular Glues
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Field of Research
Cancer; Infection; Neurological Disease
Smiles
C#CC1=CC=C(C=C1)NC(OC[C@@]23[C@H](C[C@@H]4C[C@]2([H])CN(C3)S(C5=CC=C(C(C)(C)C)C=C5)(=O)=O)C4(C)C)=O
Molecular Formula
C31H38N2O4S
Molecular Weight
534.71
References & Citations
[1]Hennes E, et al. Identification of a Monovalent Pseudo-Natural Product Degrader Class Supercharging Degradation of IDO1 by its native E3 KLHDC3. bioRxiv [Preprint]. 2025 Jan 17:2024.07.10.602857.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IDO1
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
16614156 3x 1.0 µg DNA
COMMD7 CRISPR All-in-one AAV vector set (with saCas9)(Rat)
Sign In for Pricing
View Details