IDeg-1
IDeg-1 is a molecular glucose degrading agent that targets the IDO1 protein. iDeg-1 relies on the ubiquitin-proteasome degradation pathway mediated by its natural E3 ligase KLHDC3. iDeg-1 can be used for cancer research[1].
Product Specifications
UNSPSC
12352005
Target
Indoleamine 2,3-Dioxygenase (IDO) ; Molecular Glues
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Field of Research
Cancer
Smiles
CC1=CC=C(C=C1)NC(OC[C@@]23[C@H](C[C@@H]4C[C@]2([H])CN(C3)S(C5=CC=C(C(C)(C)C)C=C5)(=O)=O)C4(C)C)=O
Molecular Formula
C30H40N2O4S
Molecular Weight
524.71
References & Citations
[1]Hennes E, et al. Identification of a Monovalent Pseudo-Natural Product Degrader Class Supercharging Degradation of IDO1 by its native E3 KLHDC3. bioRxiv [Preprint]. 2025 Jan 17:2024.07.10.602857.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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