IDeg-1

IDeg-1 is a molecular glucose degrading agent that targets the IDO1 protein. iDeg-1 relies on the ubiquitin-proteasome degradation pathway mediated by its natural E3 ligase KLHDC3. iDeg-1 can be used for cancer research[1].

Product Specifications

UNSPSC

12352005

Target

Indoleamine 2,3-Dioxygenase (IDO) ; Molecular Glues

Related Pathways

Metabolic Enzyme/Protease; PROTAC

Field of Research

Cancer

Smiles

CC1=CC=C(C=C1)NC(OC[C@@]23[C@H](C[C@@H]4C[C@]2([H])CN(C3)S(C5=CC=C(C(C)(C)C)C=C5)(=O)=O)C4(C)C)=O

Molecular Formula

C30H40N2O4S

Molecular Weight

524.71

References & Citations

[1]Hennes E, et al. Identification of a Monovalent Pseudo-Natural Product Degrader Class Supercharging Degradation of IDO1 by its native E3 KLHDC3. bioRxiv [Preprint]. 2025 Jan 17:2024.07.10.602857.