SB1349
SB1349 is a molecular glucose degrading agent that targets the Lin28 protein. SB1349 can effectively induce proteasome dependent degradation of Lin28A and Lin28B. SB1349 can increase the level of mature let-7 miRNA, downregulate the oncogenes targeted by let-7, and effectively induce the differentiation of neuroblastoma cells. SB1349 can be used for cancer research[1].
Product Specifications
UNSPSC
12352005
Target
MicroRNA; Molecular Glues
Related Pathways
Epigenetics; PROTAC
Field of Research
Cancer
Smiles
COC1=CC=C(C=C1)C(/C=C/C(N2CCN(CC2)C3=CC4=C(C5=C(C(C)(O4)C)C=NN5C6=CC=C(C=C6)C(O)=O)C=C3[N+]([O-])=O)=O)=O
Molecular Formula
C34H31N5O8
Molecular Weight
637.64
References & Citations
[1]Lee M, et al. Development of a molecular glue-based Lin28 degrader to regulate cellular proliferation and stemness. Chem Commun (Camb) . 2024 Oct 24;60 (86) :12525-12528.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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