Cyclin K degrader 2

Cyclin K degrader 2 is a molecular glucose degrading agent that targets the cyclin K protein. Cyclin K degrader 2 has inhibitory activity against CDK1 and CDK9. Cyclin K degrader 2 causes a decrease in RNA polymerase II Ser2 phosphorylation levels, downregulation of DNA damage response gene expression, accumulation of DNA damage, G1 phase arrest of the cell cycle, and apoptosis. Cyclin K degrader 2 can be used for cancer research[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; CDK; Molecular Glues

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; PROTAC

Field of Research

Cancer

Smiles

CN(C1=CC=C(C=C1)CC(NC2=NC=C(S2)SCC3=CC=CN=C3)=O)C

Molecular Formula

C19H20N4OS2

Molecular Weight

384.52

References & Citations

[1]Moison C, et al. DDB1 engagement defines the selectivity of S656 analogs for cyclin K degradation over CDK inhibition. EMBO Rep. 2025 Jun;26 (11) :2836-2854.