GSPT1 degrader-16
GSPT1 degrader-16 (Compound Lib-B-18J) is a potent and selective cereblon-based molecular glue degrader that targets G1 to S phase transition 1 (GSPT1) . GSPT1 degrader-16 shows inhibitory effect to RS4;11, Molt4, and MM.1S cells with IC50 values of 0.002, 0.26 and 0.37 μM. GSPT1 degrader-16 can be used for the research of cancer, such as acute lymphoblastic leukemi[1].
Product Specifications
CAS Number
[3060504-68-6]
UNSPSC
12352005
Target
Molecular Glues
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
O=C(N/N=C/C1=NN(C2=C1C=CC=C2)CC3=CC=CC=C3)COC4=CC=CC=C4C5=C6C(C(N(C6)C7C(NC(CC7)=O)=O)=O)=CC=C5
Molecular Formula
C36H30N6O5
Molecular Weight
626.66
References & Citations
[1]Li J, et al. A platform for the rapid synthesis of molecular glues (Rapid-Glue) under miniaturized conditions for direct biological screening. Eur J Med Chem. 2023 Oct 5;258:115567.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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