GSPT1 degrader-15
GSPT1 degrader-15 (Compound Lib-B-15O) is a potent and highly selective GSPT1 molecular gel degrader, with a DC50 of 154 nM. GSPT1 degrader-15 has almost no effect on the expression of other proteins. GSPT1 degrader-15 exhibits significant anti-proliferative activity against leukemia cells and lymphoma cells. GSPT1 degrader-15 can be used in leukemia and lymphoma research[1].
Product Specifications
CAS Number
[3060504-66-4]
UNSPSC
12352005
Target
Molecular Glues
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
O=C(NC1=O)CCC1N(C(C2=CC=C3)=O)CC2=C3C4=CC=CC=C4OCC(N/N=C/C5=CN(S(C6=CC=CC=C6)(=O)=O)C7=C5C=CC=C7)=O
Molecular Formula
C36H29N5O7S
Molecular Weight
675.71
References & Citations
[1]Li J, et al. A platform for the rapid synthesis of molecular glues (Rapid-Glue) under miniaturized conditions for direct biological screening. European journal of medicinal chemistry. 2023 Oct 5;258:115567.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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