PROTAC HDAC6 degrader 8
HDAC6 degrader-6 (Compound 11b) is a potent and selective HDAC6 PROTAC degrader with a DC50 of 1.9 nM. HDAC6 degrader-6 has no effect on the protein levels of other HDAC family members and does not degrade IKZF1, IKZF3, and GSPT1. HDAC6 degrader-6 can be used to study multiple myeloma (Pink: HDAC6 ligand (HY-177776) ; Blue: CRBN ligand (HY-W998281) ; Black: Linker) [1].
Product Specifications
UNSPSC
12352005
Target
HDAC; PROTACs
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(CCCCCCC(N/N=C/C1=CC=C(C=C1)OCCCC#CC2=CC=CC3=C2CN(C3=O)C(C(N4)=O)CCC4=O)=O)NO
Molecular Formula
C33H37N5O7
Molecular Weight
615.68
References & Citations
[1]Yang K, et al. A Cell-Based Target Engagement Assay for the Identification of Cereblon E3 Ubiquitin Ligase Ligands and Their Application in HDAC6 Degraders. Cell Chem Biol. 2020 Jul 16;27 (7) :866-876.e8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon; HDAC6
Curated Selection
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