BCL6-IN-10
BCL6-IN-10 (Compound 6) is a selective partially degradable molecular glue inhibitor that targets the BTB domain of BCL6 with an IC50 of 4 nM. BCL6-IN-10 shows anti-proliferative effect in diffuse large B-cell lymphoma (DLBCL) cell lines. BCL6-IN-10 can be used for the research of cancer [1].
Product Specifications
CAS Number
2230406-52-5
UNSPSC
12352005
Target
BCL6; Molecular Glues
Related Pathways
Immunology/Inflammation; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CNC(COC1=CC2=CC(NC3=NC(N4CCC(F)(CC4)F)=NC=C3Cl)=CC=C2N(C1=O)C)=O
Molecular Formula
C22H23ClF2N6O3
Molecular Weight
492.91
References & Citations
[1]Kerres N, et al. Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6. Cell Rep. 2017 Sep 19;20 (12) :2860-2875.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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