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BCL6-IN-10

BCL6-IN-10 (Compound 6) is a selective partially degradable molecular glue inhibitor that targets the BTB domain of BCL6 with an IC50 of 4 nM. BCL6-IN-10 shows anti-proliferative effect in diffuse large B-cell lymphoma (DLBCL) cell lines. BCL6-IN-10 can be used for the research of cancer [1].

Product Specifications

CAS Number

2230406-52-5

UNSPSC

12352005

Target

BCL6; Molecular Glues

Related Pathways

Immunology/Inflammation; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CNC(COC1=CC2=CC(NC3=NC(N4CCC(F)(CC4)F)=NC=C3Cl)=CC=C2N(C1=O)C)=O

Molecular Formula

C22H23ClF2N6O3

Molecular Weight

492.91

References & Citations

[1]Kerres N, et al. Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6. Cell Rep. 2017 Sep 19;20 (12) :2860-2875.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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