IKZF2-degrader 3
IKZF2-degrader 3 (compound 6) is a molecular glue IKZF2 degrader with a DC50 of 2.0 nM[1].
Product Specifications
CAS Number
[2983841-46-7]
UNSPSC
12352005
Target
IKZF Family; Molecular Glues
Related Pathways
Immunology/Inflammation; PROTAC
Field of Research
Inflammation/Immunology
Smiles
O=C1CCC(C(N1)=O)N2CC3=CC(C4=CC(CN5CCCC5)=C6C(C=NN6)=N4)=CC=C3C2=O
Molecular Formula
C24H24N6O3
Molecular Weight
444.49
References & Citations
[1]Zhang X, et al. Overcoming CK1α liability in the discovery of a series of isoIndolinone Glutarimides as selective IKZF2 molecular glue degraders. Bioorg Med Chem Lett. 2025 Aug 15;124:130263.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKZF2
Curated Selection
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