MeThPmR
MeThPmR, a ribonucleoside derivative, is a potent and selective human nucleoside transporter 1 (hCNT1) inhibitor (Ki/sub> = 0.16-0.69 μM) . MeThPmR exhibit weak inhibitory activity on hCNT2 (IC50 = 360 μM) and hCNT3 (Ki = 4.7 μM) . MeThPmR can protect cells from the toxicity of nucleoside drugs. MeThPmR can be used for the research of cancer[1].
Product Specifications
CAS Number
1262032-38-1
UNSPSC
12352005
Target
Nucleoside Transporters
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1N([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)C=C(C=C(C)S3)C3=N1
Molecular Formula
C12H14N2O5S
Molecular Weight
298.31
References & Citations
[1]Damaraju VL, et al. Interaction of fused-pyrimidine nucleoside analogs with human concentrative nucleoside transporters: High-affinity inhibitors of human concentrative nucleoside transporter 1. Biochem Pharmacol. 2011 Jan 1;81 (1) :82-90.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Isoform
CNT1; CNT2; CNT3
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