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GSPT2 degrader-1

GSPT2 degrader-1 (compound 619) is a selective molecular glue GSPT2 degrader targeting GSPT2. GSPT2 degrader-1 contains Thalidomide and the linker of MDEG-541 (HY-150259). GSPT2 degrader-1 induces the degradation, but not GSPT1 or myelocytomatosis oncogene (MYC). GSPT2 degrader-1 can be used for research of gastrointestinal cancer[1].

Product Specifications

CAS Number

3093413-09-0

UNSPSC

12352005

Target

Molecular Glues

Related Pathways

PROTAC

Field of Research

Cancer

Smiles

O=C1CCC(C(N1)=O)N2C(C3=CC=C(C=C3C2=O)C(NCCCCCCCCNC(C4=CC=CC=C4)=O)=O)=O

Molecular Formula

C29H32N4O6

Molecular Weight

532.59

References & Citations

[1]Lier S, et al. A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer. Bioorg Chem. 2022 Feb;119:105505.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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