GSPT2 degrader-1
GSPT2 degrader-1 (compound 619) is a selective molecular glue GSPT2 degrader targeting GSPT2. GSPT2 degrader-1 contains Thalidomide (HY-14658) and the linker of MDEG-541 (HY-150259) . GSPT2 degrader-1 induces the degradation, but not GSPT1 or myelocytomatosis oncogene (MYC) . GSPT2 degrader-1 can be used for research of gastrointestinal cancer[1].
Product Specifications
CAS Number
[3093413-09-0]
UNSPSC
12352005
Target
Molecular Glues
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
O=C1CCC(C(N1)=O)N2C(C3=CC=C(C=C3C2=O)C(NCCCCCCCCNC(C4=CC=CC=C4)=O)=O)=O
Molecular Formula
C29H32N4O6
Molecular Weight
532.59
References & Citations
[1]Lier S, et al. A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer. Bioorg Chem. 2022 Feb;119:105505.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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