LXH-3-71

LXH-3-71 is a potent molecular glue PHGDH degrader. LXH-3-71 forms a dynamic chimera between PHGDH and the DDB1-CRL E3 ligase. LXH-3-71 modulates the stemness of colorectal cancer cells (CRCs) both in vitro and in vivo. LXH-3-71 can be used for colorectal cancer research[1].

Product Specifications

CAS Number

[2251753-65-6]

UNSPSC

12352005

Target

Molecular Glues; Phosphoglycerate Dehydrogenase (PHGDH)

Related Pathways

Metabolic Enzyme/Protease; PROTAC

Field of Research

Cancer

Smiles

C=C1C[C@]2([C@@](C(C)(C)C1=O)([H])CC[C@]3(C)[C@]2([H])CC=C4[C@]5([H])CC(C)(CC[C@@]5(CC[C@]43C)C(NCCNC(NC6=CC=C(C=C6)OC)=O)=O)C)C

Molecular Formula

C41H59N3O4

Molecular Weight

657.92

References & Citations

[1]Huang Z, et al. Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH. Acta Pharm Sin B. 2024 Sep;14 (9) :4001-4013.