LXH-3-71
LXH-3-71 is a potent molecular glue PHGDH degrader. LXH-3-71 forms a dynamic chimera between PHGDH and the DDB1-CRL E3 ligase. LXH-3-71 modulates the stemness of colorectal cancer cells (CRCs) both in vitro and in vivo. LXH-3-71 can be used for colorectal cancer research[1].
Product Specifications
CAS Number
2251753-65-6
UNSPSC
12352005
Target
Molecular Glues; Phosphoglycerate Dehydrogenase (PHGDH)
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Field of Research
Cancer
Smiles
C=C1C[C@]2([C@@](C(C)(C)C1=O)([H])CC[C@]3(C)[C@]2([H])CC=C4[C@]5([H])CC(C)(CC[C@@]5(CC[C@]43C)C(NCCNC(NC6=CC=C(C=C6)OC)=O)=O)C)C
Molecular Formula
C41H59N3O4
Molecular Weight
657.92
References & Citations
[1]Huang Z, et al. Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH. Acta Pharm Sin B. 2024 Sep;14 (9) :4001-4013.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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