GSPT1 degrader-11
GSPT1 degrader-11 is a CRBN-dependent G1 to S phase transition 1 (GSPT1) molecular glue degrader (DC50 = 67.7 nM, Dmax = 97%) . GSPT1 degrader-11 can inhibit MDA-MB-231 CRBN-WT cells proliferation (IC50 = 2.07 μM) . GSPT1 degrader-11 can be used for the research of cancer[1].
Product Specifications
UNSPSC
12352005
Target
Molecular Glues
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(N4CC(N5CCC(C(N6CCN(C7=CC=C(NC8=NC=C9N=C(C%10CC%10)N(C)C9=N8)C=C7)CC6)=O)CC5)C4)=C3)=O
Molecular Formula
C41H45N11O5
Molecular Weight
771.87
References & Citations
[1]Ding B, et al. Solid-Phase Parallel Synthesis of Photocleavable Bifunctional Molecules Enables Efficient Phenotypic Protein Degrader Discovery. Angew Chem Int Ed Engl. 2025 Jul 28;64 (31) :e202424118.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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