EEF2K degrader-2
EEF2K degrader-2 is a molecular glucose degrading agent that targets the eEF2K protein. eEF2K degrader-2 can significantly inhibit the proliferation, migration, invasion and induce apoptosis of triple negative breast cancer (TNBC) cells. eEF2K degrader-2 has no obvious organ toxicity or pathological damage. eEF2K degrader-2 can be used in the research of cancer such as breast cancer[1].
Product Specifications
CAS Number
1044797-96-7
UNSPSC
12352005
Target
Apoptosis; CaMK; Molecular Glues
Related Pathways
Apoptosis; Neuronal Signaling; PROTAC
Field of Research
Cancer
Smiles
FC1=CC(CN(C2=O)C(C(C(N3CC(C(OCC)=O)CCC3)=O)=NN2C4=CC=C(C(C)=C4)C)=O)=CC=C1
Molecular Formula
C27H29FN4O5
Molecular Weight
508.54
References & Citations
[1]Zhong C, et al. Design and Characterization of a Novel eEF2K Degrader with Potent Therapeutic Efficacy Against Triple-Negative Breast Cancer. Adv Sci (Weinh) . 2024 Feb;11 (5) :e2305035.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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