EEF2K degrader-2

EEF2K degrader-2 is a molecular glucose degrading agent that targets the eEF2K protein. eEF2K degrader-2 can significantly inhibit the proliferation, migration, invasion and induce apoptosis of triple negative breast cancer (TNBC) cells. eEF2K degrader-2 has no obvious organ toxicity or pathological damage. eEF2K degrader-2 can be used in the research of cancer such as breast cancer[1].

Product Specifications

CAS Number

[1044797-96-7]

UNSPSC

12352005

Target

Apoptosis; CaMK; Molecular Glues

Related Pathways

Apoptosis; Neuronal Signaling; PROTAC

Field of Research

Cancer

Smiles

FC1=CC(CN(C2=O)C(C(C(N3CC(C(OCC)=O)CCC3)=O)=NN2C4=CC=C(C(C)=C4)C)=O)=CC=C1

Molecular Formula

C27H29FN4O5

Molecular Weight

508.54

References & Citations

[1]Zhong C, et al. Design and Characterization of a Novel eEF2K Degrader with Potent Therapeutic Efficacy Against Triple-Negative Breast Cancer. Adv Sci (Weinh) . 2024 Feb;11 (5) :e2305035.