14-Acetoxy parthenolide
14-Acetoxy parthenolide (compound 6a) is a parthenolide (PTL) derivative. 14-Acetoxy parthenolide exhibits potent anti-acute myeloid leukemia (AML) activity against HL-60 and KG1a cells, with IC50 values of 2.8 µM and 6.3 µM, respectively. 14-Acetoxy parthenolide can be used for AML research[1].
Product Specifications
CAS Number
2064236-08-2
UNSPSC
12352005
Target
Drug Derivative
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
[H][C@]12O[C@]1(C)CC/C=C(CC[C@]3(C(C(O[C@@]32[H])=O)=C)[H])/COC(C)=O
Molecular Formula
C17H22O5
Molecular Weight
306.35
References & Citations
[1]Yang Z, et al. Synthesis and anti-acute myeloid leukemia activity of C-14 modified parthenolide derivatives. Eur J Med Chem. 2017 Feb 15;127:296-304.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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