14-Acetoxy parthenolide

14-Acetoxy parthenolide (compound 6a) is a parthenolide (PTL) derivative. 14-Acetoxy parthenolide exhibits potent anti-acute myeloid leukemia (AML) activity against HL-60 and KG1a cells, with IC50 values of 2.8 µM and 6.3 µM, respectively. 14-Acetoxy parthenolide can be used for AML research[1].

Product Specifications

CAS Number

[2064236-08-2]

UNSPSC

12352005

Target

Drug Derivative

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

[H][C@]12O[C@]1(C)CC/C=C(CC[C@]3(C(C(O[C@@]32[H])=O)=C)[H])/COC(C)=O

Molecular Formula

C17H22O5

Molecular Weight

306.35

References & Citations

[1]Yang Z, et al. Synthesis and anti-acute myeloid leukemia activity of C-14 modified parthenolide derivatives. Eur J Med Chem. 2017 Feb 15;127:296-304.