PROTAC AR Degrader-11
PROTAC AR Degrader-11 is a potent androgen receptor and androgen receptor splice variant-7 PROTAC degrader. PROTAC AR Degrader-11 shows potent cytotoxicity against both CWR22RV1 cells and VCaP cells. PROTAC AR Degrader-11 can be used in prostate cancer research[1]. (Structure Note: Pink: Androgen Receptor ligand (HY-171809) ; Blue: CRBN ligand (HY-A0003) ; Black: linker (HY-169966) )
Product Specifications
CAS Number
[2798907-41-0]
UNSPSC
12352005
Target
Androgen Receptor; PROTACs
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(COCCCCOC1=CC=C(C2CCN(CC2)C3=NN4C(CC3)=NN=C4C(F)(F)F)C=C1)NC5=CC=CC6=C5CN(C7C(NC(CC7)=O)=O)C6=O
Molecular Formula
C36H39F3N8O6
Molecular Weight
736.74
References & Citations
[1]Chih-Wei Fu, et al. Androgen receptor binding bifunctional molecules. EP4023649A1. 2021-12-23
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-177694/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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