N- (NHS-PEG4) -N- (PEG4-Val-Cit-PAB-MMAF) -N- (PEG4-Val-Cit-PAB-Exatecan)
N- (NHS-PEG4) -N- (PEG4-Val-Cit-PAB-MMAF) -N- (PEG4-Val-Cit-PAB-Exatecan) is a drug-linker conjugate for ADC (Drug-Linker Conjugate for ADC), consisting of a tubulin polymerization inhibitor MMAE and a DNA topoisomerase I inhibitor Exatecan (HY-13631), and an ADC linker composition. N- (NHS-PEG4) -N- (PEG4-Val-Cit-PAB-MMAF) -N- (PEG4-Val-Cit-PAB-Exatecan) can be used for synthesis of ADCs and for cancer research.
Product Specifications
UNSPSC
12352005
Target
Drug-Linker Conjugates for ADC; Microtubule/Tubulin; Topoisomerase
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Smiles
O=C(N[C@@H](C(C)C)C(N[C@H](C(NC1=CC=C(COC(N(C)[C@H](C(N[C@@H](C(C)C)C(N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N2[C@H]([C@H](OC)[C@@H](C)C(N[C@@H](CC3=CC=CC=C3)C(O)=O)=O)CCC2)=O)C)=O)=O)C(C)C)=O)C=C1)=O)CCCNC(N)=O)=O)CCOCCOCCOCCOCCC(N(CCOCCOCCOCCOCCC(ON4C(CCC4=O)=O)=O)CCOCCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC(C=C5)=CC=C5COC(N[C@H]6CCC7=C8C6=C9C(C(N%10C9)=CC([C@](CC)(O)C(OC%11)=O)=C%11C%10=O)=NC8=CC(F)=C7C)=O)=O)=O)=O)=O
Molecular Formula
C139H203FN20O41
Molecular Weight
2829.21
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Frequently Asked Questions
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