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N- (Azido-PEG4) -N- (PEG4-Val-Cit-PAB-MMAF) -N- (PEG4-Val-Cit-PAB-Exatecan)

N- (Azido-PEG4) -N- (PEG4-Val-Cit-PAB-MMAF) -N- (PEG4-Val-Cit-PAB-Exatecan) is a drug-linker conjugate for ADC (Drug-Linker Conjugate for ADC), consisting of a tubulin polymerization inhibitor MMAE (HY-15162) and a DNA topoisomerase I inhibitor Exatecan (HY-13631), and an ADC linker composition. N- (Azido-PEG4) -N- (PEG4-Val-Cit-PAB-MMAF) -N- (PEG4-Val-Cit-PAB-Exatecan) can be used for synthesis of ADCs and for cancer research.

Product Specifications

UNSPSC

12352005

Target

Drug-Linker Conjugates for ADC; Microtubule/Tubulin; Topoisomerase

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Smiles

O=C(N[C@@H](C(C)C)C(N[C@H](C(NC1=CC=C(COC(N(C)[C@H](C(N[C@@H](C(C)C)C(N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N2[C@H]([C@H](OC)[C@@H](C)C(N[C@@H](CC3=CC=CC=C3)C(O)=O)=O)CCC2)=O)C)=O)=O)C(C)C)=O)C=C1)=O)CCCNC(N)=O)=O)CCOCCOCCOCCOCCC(N(CCOCCOCCOCCOCCN=[N+]=[N-])CCOCCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC(C=C4)=CC=C4COC(N[C@H]5CCC6=C7C5=C8C(C(N9C8)=CC([C@](CC)(O)C(OC%10)=O)=C%10C9=O)=NC7=CC(F)=C6C)=O)=O)=O)=O)=O

Molecular Formula

C134H199FN22O37

Molecular Weight

2729.14

Shipping Conditions

Room temperature

Scientific Category

ADC Related

Clinical Information

No Development Reported

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