N- (DBCO-PEG4) -N- (PEG4-Val-Cit-PAB-MMAE) -N- (PEG4-Val-Cit-PAB-Exatecan)
N- (DBCO-PEG4) -N- (PEG4-Val-Cit-PAB-MMAE) -N- (PEG4-Val-Cit-PAB-Exatecan) is a drug-linker conjugate for ADC (Drug-Linker Conjugate for ADC), consisting of a tubulin polymerization inhibitor MMAE and a DNA topoisomerase I inhibitor Exatecan (HY-13631), and an ADC linker composition. N- (DBCO-PEG4) -N- (PEG4-Val-Cit-PAB-MMAE) -N- (PEG4-Val-Cit-PAB-Exatecan) can be used for synthesis of ADCs and for cancer research.
Product Specifications
UNSPSC
12352005
Target
Drug-Linker Conjugates for ADC; Microtubule/Tubulin; Topoisomerase
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Smiles
CN([C@@H]([C@@H](C)CC)[C@H](OC)CC(N1[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)CCC1)=O)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@@H](NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCC(N(CCOCCOCCOCCOCCNC(CCC(N4CC(C=CC=C5)=C5C#CC6=C4C=CC=C6)=O)=O)CCOCCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC(C=C7)=CC=C7COC(N[C@H]8CCC9=C%10C8=C%11C(C(N%12C%11)=CC([C@](CC)(O)C(OC%13)=O)=C%13C%12=O)=NC%10=CC(F)=C9C)=O)=O)=O)=O)=O)=O)=O)CCCNC(N)=O)=O)=O)=O)=O
Molecular Formula
C153H216FN21O38
Molecular Weight
2976.47
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Frequently Asked Questions
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