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N- (Azido-PEG4) -N- (PEG4-Val-Cit-PAB-MMAE) -N- (PEG4-Val-Cit-PAB-Exatecan)

N- (Azido-PEG4) -N- (PEG4-Val-Cit-PAB-MMAE) -N- (PEG4-Val-Cit-PAB-Exatecan) is a drug-linker conjugate for ADC (Drug-Linker Conjugate for ADC), consisting of a tubulin polymerization inhibitor MMAE (HY-15162) and a DNA topoisomerase I inhibitor Exatecan (HY-13631), and an ADC linker composition. N- (Azido-PEG4) -N- (PEG4-Val-Cit-PAB-MMAE) -N- (PEG4-Val-Cit-PAB-Exatecan) can be used for synthesis of ADCs and for cancer research.

Product Specifications

UNSPSC

12352005

Target

Drug-Linker Conjugates for ADC; Microtubule/Tubulin; Topoisomerase

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Smiles

CN([C@@H]([C@@H](C)CC)[C@H](OC)CC(N1[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)CCC1)=O)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@@H](NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCC(N(CCOCCOCCOCCOCCN=[N+]=[N-])CCOCCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC(C=C4)=CC=C4COC(N[C@H]5CCC6=C7C5=C8C(C(N9C8)=CC([C@](CC)(O)C(OC%10)=O)=C%10C9=O)=NC7=CC(F)=C6C)=O)=O)=O)=O)=O)=O)=O)CCCNC(N)=O)=O)=O)=O)=O

Molecular Formula

C134H201FN22O36

Molecular Weight

2715.15

Shipping Conditions

Room temperature

Scientific Category

ADC Related

Clinical Information

No Development Reported

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