Solbinsiran

Solbinsiran is a siRNA targeted to hepatic ANGPTL3.

Product Specifications

CAS Number

[2718150-11-7]

Product Name Alternative

LY3561774

UNSPSC

12352208

Target

ANGPTL

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

[Solbinsiran]

Molecular Formula

C653H859O412N229F11P57S6

Molecular Weight

20674.90

References & Citations

[1]Ray KK, Oru E, Rosenson RS, et al. Durability and efficacy of solbinsiran, a GalNAc-conjugated siRNA targeted to ANGPTL3, in adults with mixed dyslipidaemia (PROLONG-ANG3) : a double-blind, randomised, placebo-controlled, phase 2 trial. Lancet. 2025;405 (10489) :1594-1607.|[2]Ray KK, Linnebjerg H, Michael LF, et al. Effect of ANGPTL3 Inhibition With Solbinsiran in Preclinical and Early Human Studies. J Am Coll Cardiol. 2025;85 (19) :1803-1818.