Sapablursen (sodium)

Sapablursen sodium, an antisense oligonucleotide, is designed to reduce the production of TMPRSS6 resulting in increased expression of hepcidin, which is the key regulator of iron homeostasis. Sapablursen sodium can be used in the research of blood diseas

Product Specifications

CAS Number

[2273008-00-5]

Product Name Alternative

IONIS-TMPRSS6-Lrx sodium; ISIS 702843 sodium

UNSPSC

12352208

Target

TMPRSS6

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

[Sapablursen(sodium)]

Molecular Formula

C296H416N80Na20O155P20S13

Molecular Weight

9071.01

References & Citations

[1]Zanardi TA, Korbmacher B, Boone L, et al. Safety, Pharmacokinetic, and Pharmacodynamic Evaluation of a 2'- (2-Methoxyethyl) -D-ribose Antisense Oligonucleotide-Triantenarry N-Acetyl-galactosamine Conjugate that Targets the Human Transmembrane Protease Serine 6. J Pharmacol Exp Ther. 2021;377 (1) :51-63.