Sapablursen
Sapablursen, an antisense oligonucleotide, is designed to reduce the production of TMPRSS6 resulting in increased expression of hepcidin, which is the key regulator of iron homeostasis. Sapablursen can be used in the research of blood diseases such as pol
Product Specifications
CAS Number
2273007-95-5
Product Name Alternative
IONIS-TMPRSS6-Lrx; ISIS 702843
UNSPSC
12352208
Target
TMPRSS6
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
[Sapablursen]
Molecular Formula
C296H436N80O155P20S13
Molecular Weight
8631.38
References & Citations
[1]Zanardi TA, Korbmacher B, Boone L, et al. Safety, Pharmacokinetic, and Pharmacodynamic Evaluation of a 2'- (2-Methoxyethyl) -D-ribose Antisense Oligonucleotide-Triantenarry N-Acetyl-galactosamine Conjugate that Targets the Human Transmembrane Protease Serine 6. J Pharmacol Exp Ther. 2021;377 (1) :51-63.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
Phase 2
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