Sapablursen

Sapablursen, an antisense oligonucleotide, is designed to reduce the production of TMPRSS6 resulting in increased expression of hepcidin, which is the key regulator of iron homeostasis. Sapablursen can be used in the research of blood diseases such as pol

Product Specifications

CAS Number

[2273007-95-5]

Product Name Alternative

IONIS-TMPRSS6-Lrx; ISIS 702843

UNSPSC

12352208

Target

TMPRSS6

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

[Sapablursen]

Molecular Formula

C296H436N80O155P20S13

Molecular Weight

8631.38

References & Citations

[1]Zanardi TA, Korbmacher B, Boone L, et al. Safety, Pharmacokinetic, and Pharmacodynamic Evaluation of a 2'- (2-Methoxyethyl) -D-ribose Antisense Oligonucleotide-Triantenarry N-Acetyl-galactosamine Conjugate that Targets the Human Transmembrane Protease Serine 6. J Pharmacol Exp Ther. 2021;377 (1) :51-63.