Frenlosirsen

Frenlosirsen is an antisense oligonucleotide targeted to IRF4. It is used for study of relapsed/refractory multiple myeloma (RRMM) .

Product Specifications

CAS Number

[2304711-81-5]

Product Name Alternative

ION-935918; ION251

UNSPSC

12352208

Target

IFNAR

Related Pathways

Immunology/Inflammation

Field of Research

Cancer

Smiles

[Frenlosirsen]

Molecular Formula

C177H226N63O89P15S15

Molecular Weight

5605.63

References & Citations

[1]Alexander A. Tong, Silvia Vicenzi, Lara C. Avsharian, Joshua D. Hartman, Trung V. Tran, Ashni A. Vora, Robert A. Vescio, Barry A. Paul, Caitlin L. Costello, T. Jesse Kwoh, Leslie A. Crews; Abstract CT146: Safety, tolerability and molecular correlates of the IRF4-targeted antisense oligonucleotide frenlosirsen in patients with relapsed/refractory multiple myeloma: A phase 1a dose escalation trial. Cancer Res 15 April 2025; 85 (8_Supplement_2) : CT146.