Etidaligide (sodium)
Etidaligide sodium, an AsiDNA, a first-in-class DNA repair inhibitor designed to prevent the repair of DNA damage in tumour cells. It also activates DNA-dependent protein kinase (DNA-PK) and poly (ADP-ribose) polymerase enzymes that induce phosphorylation
Product Specifications
Product Name Alternative
DT01 (sodium) ; coDbait (sodium)
UNSPSC
12352208
Target
Poly (ADP-ribose) Glycohydrolase (PARG)
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
[Etidaligide(sodium)]
References & Citations
[1]Le Tourneau, C., Delord, JP., Kotecki, N. et al. A Phase 1 dose-escalation study to evaluate safety, pharmacokinetics and pharmacodynamics of AsiDNA, a first-in-class DNA repair inhibitor, administered intravenously in patients with advanced solid tumours. Br J Cancer 123, 1481–1489 (2020) .|[2]Herath NI, Devun F, Lienafa MC, et al. The DNA Repair Inhibitor DT01 as a Novel Therapeutic Strategy for Chemosensitization of Colorectal Liver Metastasis. Mol Cancer Ther. 2016;15 (1) :15-22.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
Phase 2
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb3053791-01 20 µg
Recombinant Human Interleukin-33 (IL33), partial
Sign In for Pricing
View Details orb3053791-02 100 µg
Recombinant Human Interleukin-33 (IL33), partial
Sign In for Pricing
View Details orb3053791-03 1 mg
Recombinant Human Interleukin-33 (IL33), partial
Sign In for Pricing
View Details AZA0A8M1RFS1-PE 100 µg/Vial
Anti-Zebrafish p21/CDKN1A Antibody Picoband® PE Conjugated
Sign In for Pricing
View Details 047508-01 10 µg
FGF-2/FGFb, Recombinant, Human, aa143-288, Active discontinued
Sign In for Pricing
View Details 047508-02 50 µg
FGF-2/FGFb, Recombinant, Human, aa143-288, Active discontinued
Sign In for Pricing
View Details