Etidaligide
Etidaligide, an AsiDNA, a first-in-class DNA repair inhibitor designed to prevent the repair of DNA damage in tumour cells. It also activates DNA-dependent protein kinase (DNA-PK) and poly (ADP-ribose) polymerase enzymes that induce phosphorylation of H2A
Product Specifications
CAS Number
1974402-87-3
Product Name Alternative
DT01; coDbait
UNSPSC
12352208
Target
Poly (ADP-ribose) Glycohydrolase (PARG)
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
[Etidaligide]
References & Citations
[1]Le Tourneau, C., Delord, JP., Kotecki, N. et al. A Phase 1 dose-escalation study to evaluate safety, pharmacokinetics and pharmacodynamics of AsiDNA, a first-in-class DNA repair inhibitor, administered intravenously in patients with advanced solid tumours. Br J Cancer 123, 1481–1489 (2020) .|[2]Herath NI, Devun F, Lienafa MC, et al. The DNA Repair Inhibitor DT01 as a Novel Therapeutic Strategy for Chemosensitization of Colorectal Liver Metastasis. Mol Cancer Ther. 2016;15 (1) :15-22.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
Phase 2
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