Etidaligide

Etidaligide, an AsiDNA, a first-in-class DNA repair inhibitor designed to prevent the repair of DNA damage in tumour cells. It also activates DNA-dependent protein kinase (DNA-PK) and poly (ADP-ribose) polymerase enzymes that induce phosphorylation of H2A

Product Specifications

CAS Number

[1974402-87-3]

Product Name Alternative

DT01; coDbait

UNSPSC

12352208

Target

Poly (ADP-ribose) Glycohydrolase (PARG)

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

[Etidaligide]

References & Citations

[1]Le Tourneau, C., Delord, JP., Kotecki, N. et al. A Phase 1 dose-escalation study to evaluate safety, pharmacokinetics and pharmacodynamics of AsiDNA, a first-in-class DNA repair inhibitor, administered intravenously in patients with advanced solid tumours. Br J Cancer 123, 1481–1489 (2020) .|[2]Herath NI, Devun F, Lienafa MC, et al. The DNA Repair Inhibitor DT01 as a Novel Therapeutic Strategy for Chemosensitization of Colorectal Liver Metastasis. Mol Cancer Ther. 2016;15 (1) :15-22.