Edifoligide

Edifoligide is a decoy oligonucleotide that binds to and inhibits E2F transcription factors and thus may prevent neointimal hyperplasia and vein graft failure

Product Specifications

CAS Number

[328538-04-1]

Product Name Alternative

CGT 003

UNSPSC

12352208

Target

Early 2 Factor (E2F)

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Inflammation/Immunology

Smiles

[Edifoligide]

References & Citations

[1]Lopes RD, Williams JB, Mehta RH, et al. Edifoligide and long-term outcomes after coronary artery bypass grafting: PRoject of Ex-vivo Vein graft ENgineering via Transfection IV (PREVENT IV) 5-year results. Am Heart J. 2012;164 (3) :379-386.e1.|[2]Alexander JH, Hafley G, Harrington RA, et al. Efficacy and safety of edifoligide, an E2F transcription factor decoy, for prevention of vein graft failure following coronary artery bypass graft surgery: PREVENT IV: a randomized controlled trial. JAMA. 2005;294 (19) :2446-2454.

Shipping Conditions

Room temperature

Scientific Category

Oligonucleotides

Clinical Information

Phase 3