ALN-12115

ALN-12115 is a siRNA that targets kinesin spindle protein (KSP), and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for KSP and VEGF with potential antitumor activity.

Product Specifications

CAS Number

[3031494-36-4]

Product Name Alternative

AD12115

UNSPSC

12352208

Target

Kinesin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

[ALN-12115]

References & Citations

[1]COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Eg5 GENE. US20110015250A1|[2]Tabernero J, Shapiro GI, LoRusso PM, et al. First-in-humans trial of an RNA interference therapeutic targeted to VEGF and KSP in cancer patients with liver involvement. Cancer Discov. 2013;3 (4) :406-417.