Afovirsen (sodium)

Afovirsen sodium is a 20-mer phosphorothioate oligonucleotide. It is complementary to the mRNA sequence for the translation initiation codon of the E2 protein vital to replication of HPV types 6 and 11.

Product Specifications

CAS Number

[138330-98-0]

Product Name Alternative

ISIS 2105 (sodium)

UNSPSC

12352208

Target

HPV

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

[Afovirsen(sodium)]

Molecular Formula

C192H250N57O107P19S19Na19

Molecular Weight

6702.89

References & Citations

[1]Crooke ST, Grillone LR, Tendolkar A, et al. A pharmacokinetic evaluation of 14C-labeled afovirsen sodium in patients with genital warts. Clin Pharmacol Ther. 1994;56 (6 Pt 1) :641-646.|[2]Crooke RM, Graham MJ, Cooke ME, Crooke ST. In vitro pharmacokinetics of phosphorothioate antisense oligonucleotides. J Pharmacol Exp Ther. 1995;275 (1) :462-473.