Afovirsen (sodium)
Afovirsen sodium is a 20-mer phosphorothioate oligonucleotide. It is complementary to the mRNA sequence for the translation initiation codon of the E2 protein vital to replication of HPV types 6 and 11.
Product Specifications
CAS Number
[138330-98-0]
Product Name Alternative
ISIS 2105 (sodium)
UNSPSC
12352208
Target
HPV
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
[Afovirsen(sodium)]
Molecular Formula
C192H250N57O107P19S19Na19
Molecular Weight
6702.89
References & Citations
[1]Crooke ST, Grillone LR, Tendolkar A, et al. A pharmacokinetic evaluation of 14C-labeled afovirsen sodium in patients with genital warts. Clin Pharmacol Ther. 1994;56 (6 Pt 1) :641-646.|[2]Crooke RM, Graham MJ, Cooke ME, Crooke ST. In vitro pharmacokinetics of phosphorothioate antisense oligonucleotides. J Pharmacol Exp Ther. 1995;275 (1) :462-473.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Curated Selection
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